Interactions between acetylenic compounds and a synthesized tungsten(IV) model complex : implications to the reaction mechanism of acetylene hydratase
Tungsten is the only known 3rd row transition metal currently found in metalloenzymes; all tungsten metalloenzymes known to date are primarily found in anaerobic, thermophilic bacteria and hyperthermophilic archaea. Mononuclear tungsten and molybdenum metalloenzymes contain a sulfur-rich coordination sphere composed of at least one pyranopterindithiolate cofactor, chalcogen donors, and a protein-bound amino acid. Acetylene hydratase is a tungstoenzyme that catalyzes a net nonredox reaction, the hydration of acetylene to acetaldehyde. Acetylene hydratase (AH) is unique in that it is the only known ...