Now showing items 1-5 of 5
Characterizing the role of the HspX protein from Mycobacterium tuberculosis as a subunit vaccine candidate in the small animal model of tuberculosis
Contributor:Wieczorek, Agatha E.
Tuberculosis (TB) is a bacterial disease of the lung, caused by Mycobacterium tuberculosis, and currently remains an important human pathogen. The only vaccine against tuberculosis licensed for human use is a live, attenuated ...
Characterization and quantification of urinary metabolic biomarkers for early response to anti-tuberculosis treatment
Development of new anti-tuberculosis (TB) therapies remains a major priority to combat this infectious disease and to prevent continued transmission of the causative agent Mycobacterium tuberculosis (Mtb). However, newly ...
Novel extracellular products of Mycobacterium tuberculosis : composition, synthesis, and relevance to disease
Mycobacterium tuberculosis (Mtb) is a bacterium causing great morbidity and mortality especially in developing countries. In order to identify possible areas of intervention to positively alter the history of the disease, ...
Bioinformatic identification and characterization of cytokinetic regulators in Mtb
Contributor:Crew, Rebecca M.
A fundamental lack of understanding of Mtb regulation during latent tuberculosis infections (LTBI), which comprises the vast majority of tuberculosis cases, has hindered global eradication efforts. To elucidate mechanisms ...
Host directed therapy targeting M. tuberculosis infected macrophages
With the rise of drug resistant strains of Mycobacterium tuberculosis (Mtb) and lags in antimicrobial drug development, it is imperative to explore alternative methods of treatment through host-directed adjunct therapies. ...