Now showing items 1-5 of 5
Folate pathway inhibitor resistance mechanisms in Burkholderia pseudomallei
Contributor:Podnecky, Nicole L.
Antimicrobials are invaluable tools used to facilitate the treatment of infectious diseases. Their use has saved millions of lives since their introduction in the early 1900's. Unfortunately, due to the increased incidence ...
Investigation of innate immunity, mucosal therapeutics and pathogenesis of select agent Burkholderia species
Contributor:Goodyear, Andrew Whitman
Burkholderia mallei and B. pseudomallei are important human pathogens and cause the diseases glanders and melioidosis, respectively. Both organisms are gram-negative bacteria and due to their potential use as bioweapons ...
Sub-cellular localization of the PenA β-lactamase in Burkholderia pseudomallei
Contributor:Randall, Linnell B.
Burkholderia pseudomallei, a Gram-negative soil bacterium found in tropical regions, is the etiologic agent of melioidosis. B. pseudomallei is intrinsically resistant to many antibiotics, and melioidosis treatment involves ...
Mechanisms of IFN-γ and ceftazidime interaction for synergistic killing of Burkholderia
Burkholderia pseudomallei is a Gram negative, facultative intracellular pathogen which infects both phagocytes and non-phagocytes and causes severe acute infections in humans and animals. Due to its inherent resistance ...
Analysis of Burkholderia pseudomallei virulence and efficacy of potential therapeutics, The
Contributor:Propst, Katie L.
Burkholderia pseudomallei is the causative agent of the disease melioidosis and is classified as a category B Select Agent. There are currently many challenges associated with both the study of this pathogen and its treatment ...