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Novel extracellular products of Mycobacterium tuberculosis: composition, synthesis, and relevance to disease
Author(s):Obregón-Henao, Andrés
Date Issued:2013
Format:born digital; doctoral dissertations
Mycobacterium tuberculosis (Mtb) is a bacterium causing great morbidity and mortality especially in developing countries. In order to identify possible areas of intervention to positively alter the history of the disease, ...
Characterizing the role of the HspX protein from Mycobacterium tuberculosis as a subunit vaccine candidate in the small animal model of tuberculosis
Author(s):Wieczorek, Agatha E.
Date Issued:2011
Format:born digital; masters theses
Tuberculosis (TB) is a bacterial disease of the lung, caused by Mycobacterium tuberculosis, and currently remains an important human pathogen. The only vaccine against tuberculosis licensed for human use is a live, attenuated ...
Mycobacterium tuberculosis – mediated modulation of host macrophage metabolism in the granuloma microenvironment
Author(s):Kiran, Dilara
Date Issued:2020
Format:born digital; masters theses
Mycobacterium tuberculosis (Mtb) is the leading cause of death by an infectious agent, and tuberculosis (TB) disease continues to be a prominent global health concern. Infection with Mtb incites granulomatous inflammation, ...
Comprehensive characterization of Mycobacterium tuberculosis strains after acquisition of isoniazid resistance
Author(s):Nieto Ramirez, Luisa Maria
Date Issued:2016
Format:born digital; doctoral dissertations
Despite the global efforts to reduce tuberculosis (TB) rates, the emergence of drug resistant TB has not allowed effective control of this disease. In the last decade, there were roughly 10 million new TB cases per year ...
Characterization and quantification of urinary metabolic biomarkers for early response to anti-tuberculosis treatment
Author(s):Fitzgerald, Bryna
Date Issued:2016
Format:born digital; doctoral dissertations
Development of new anti-tuberculosis (TB) therapies remains a major priority to combat this infectious disease and to prevent continued transmission of the causative agent Mycobacterium tuberculosis (Mtb). However, newly ...
Host directed therapy targeting M. tuberculosis infected macrophages
Author(s):Lakey, Natalie
Date Issued:2016
Format:born digital; masters theses
With the rise of drug resistant strains of Mycobacterium tuberculosis (Mtb) and lags in antimicrobial drug development, it is imperative to explore alternative methods of treatment through host-directed adjunct therapies. ...
Bioinformatic identification and characterization of cytokinetic regulators in Mtb
Author(s):Crew, Rebecca M.
Date Issued:2013
Format:born digital; masters theses
A fundamental lack of understanding of Mtb regulation during latent tuberculosis infections (LTBI), which comprises the vast majority of tuberculosis cases, has hindered global eradication efforts. To elucidate mechanisms ...
Exosomes: a potential novel source of biomarkers for tuberculosis
Author(s):Diaz, Gustavo
Date Issued:2017
Format:born digital; doctoral dissertations
To view the abstract, please see the full text of the document.
Targeted computational analysis of the C3HEB/FEJ mouse model for drug efficacy testing
Author(s):Asay, Bryce Clifford
Date Issued:2020
Format:born digital; doctoral dissertations
Efforts to develop effective and safe drugs for the treatment of tuberculosis (TB) require preclinical evaluation in animal models. Alongside efficacy testing of novel therapies, effects on pulmonary pathology and disease ...
Metformin: a tool to better understand T cell mediated protection against Mycobacterium tuberculosis
Author(s):Haugen Frenkel, Jessica D.
Date Issued:2020
Format:born digital; doctoral dissertations
To view the abstract, please see the full text of the document.