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Arthropod-borne viruses (arboviruses) are distinctive in that they are required to constantly replicate in different hosts and in a wide range of temperatures for their perpetuation in nature. Vertebrate hosts tend to ...

This chapter details cell-cell communication highlighting studies performed in the model organism Dictyostelium discoideum. Topics covered include signaling molecules, cell surface receptors, and subversion of host cell ...

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Protein kinase C, a family of intracellular signal transducing proteins, are critical for a myriad of cellular actions with implications in both diabetes and its complications. The isoform PKCθ is enriched in T lymphocytes ...

Osteoarthritis (OA) is a degenerative joint disease affecting nearly 250 million people globally. With clinical signs of severe and persistent joint pain, OA is a leading cause of physical disability throughout the world. ...

Most pathogens enter the body at the mucosa and induce innate and adaptive immune responses at these surfaces essential for protection against infection and disease. Induction of mucosal immune responses is best achieved ...

Mycobacterium tuberculosis (Mtb) is the leading cause of death by an infectious agent, and tuberculosis (TB) disease continues to be a prominent global health concern. Infection with Mtb incites granulomatous inflammation, ...

There are major public health concerns regarding the spread of mosquito-borne diseases such as dengue, Zika, and chikungunya. The primary method to reduce the spread of these diseases is by killing the major mosquito ...

Mycobacterium abscessus is a bacterial pathogen emerging in humans. The bacterium is difficult to treat, and it results in increased mortality. The patient case rates of diseases associated with this bacterium are increasing. ...