Now showing items 1-6 of 6
Oxidative and energetic stress : regulation of Nrf2 and mitochondrial biogenesis for slowed aging interventions
Contributor:Bruns, Danielle Reuland
The following dissertation describes a series of experiments with the overall aim to understand the cellular energetic and oxidative stresses associated with aging, and to investigate treatments which may attenuate these ...
Acute ascorbic acid administration improves exercise hyperemia during rhythmic but not single contractions in aging humans
Contributor:Simpson, Carrie Beth
Age-related increases in oxidative stress are known to impair endothelium dependent vasodilation in older healthy humans. As a result, many researchers have speculated that endothelial dysfunction contributes to impaired ...
On the role of circulating ATP in vascular control at rest and during exercise of aging humans
Contributor:Kirby, Brett Sean
The following investigation composes a series of experiments with the overall aim of determining the role for the circulating nucleotide adenosine triphosphate (ATP) in vascular control at rest and during exercise in humans ...
Protein synthesis rates in response to exercise and β-adrenergic signaling in human skeletal muscle
Contributor:Robinson, Matthew McHutcheson
Skeletal muscle protein turnover is determined by the synthesis and degradation of skeletal muscle proteins and is the mechanism that determines skeletal muscle protein content. A loss of skeletal muscle mass and function ...
Neuromuscular dysfunction : characterization and rehabilitation
Contributor:Paxton, Roger John
Manifestation of action in the physical world is reliant on afferent signaling, processing, efferent signaling, and transduction of this signal into force production and control at the musculature. A variety of neural ...
Protein synthesis in slowed aging : insights into shared characteristics of long-lived mouse models
Contributor:Drake, Joshua Chadwick
The following dissertation describes a series of experiments with the overall aim to understand the role that changes in protein synthesis have in slowed aging. The specific aims of the three sets of experiments were 1) ...