Graduate Degree Program in Cell & Molecular Biology: Recent submissions
Now showing items 21-40 of 128
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Design and quantification of a tissue type specific genetic circuit in plants
Synthetic biologists aim to rationally design genetic circuits and utilize plant platforms to photosynthetically drive, self-sustainable circuits. Although plants are excellent platforms, issues and unpredictability arise ... -
Characterization the role of telomeric RNA (TERRA) in telomeric DNA double-strand break (DSB) repair in human ALT (telomerase independent) cells
Telomeres are specialized nucleoprotein complexes that protect natural chromosomal termini from degradation and prevent their detection as of DNA damage. Therefore, telomeres play critical roles in maintaining genomic ... -
Investigating the regulators of cytoplasmic dynein
Organization of the cell is a dynamic and complex process that is often underappreciated. To accomplish this, cells use motor proteins to move different cargo to their destination. Cytoplasmic dynein is one such motor ... -
PH-dependent activity and the protonophoric mechanism of pyrazinoic acid and its structural analogues, The
Pyrazinamide is an anti tubercle drug used in the standard treatment regimen against Mycobacterium tuberculosis, the cause of tuberculosis infections. The mechanism of action of pyrazinamide requires its enzymatic conversion ... -
Influence and regulation of PCBP2 and YTHDF2 RNA-binding proteins during self-renewal and differentiation of human induced pluripotent stem cells
Embryonic stem cells (ESCs) are able to self-renew or differentiate into any cell type in the body, a property known as pluripotency that enables them to initiate early growth and development. However, the ethical implications ... -
Effects of luteinizing hormone receptor expression levels on receptor aggregation and function
Luteinizing hormone receptors (LHR) are G protein-coupled receptors (GPCR) found primarily in female and male reproductive organs where they play a critical role in ovulation and sperm maturation, respectively, as well as ... -
DXO decapping exonuclease is a restriction factor for RNA viruses, The
Cellular RNA exonucleases, such as XRN1 and DXO, aid in the destruction of defective cellular mRNAs and help maintain overall cellular health. The RNA decay system, however, also serves another purpose – degrading viral ... -
Gene expression regulation by a stress-responsive transcription factor in rice seedlings
Stress physiology is an inherently complex field. As plants cannot leave their environment when it becomes unfavorable, they have developed multiple mechanisms to cope with stresses. Many of these are unique to plants ... -
Novel in vitro approaches to delineate prion strain conformational variation
Prions cause in invariably lethal, transmissible neurodegenerative diseases. There are no effective treatments or cures for prion diseases. Unlike other known pathogens, prions replicate in the absence of nucleic acids. ... -
Effect of aging on metabolic status and hormone responsiveness in the ovary
There were significant effects of mares' ages on gene expression in granolosa cells. Most of the effects we noted were on the expression of AMPK subunits, italics indicating genes rather than gene protein products, although ... -
Signaling complexes formed by luteinizing hormone receptor trans-activation
Signal transduction by luteinizing hormone (LH) receptors depends on hormone activation of these receptors, a process important for mammalian reproduction. The LH receptor, a member of the G protein-coupled receptor (GPCR) ... -
Impact of insulin like growth factor 2 mRNA binding protein 1 (IGF2BP1) in human and canine osteosarcoma, The
Osteosarcoma (OS) is a malignant bone tumor that afflicts over 10,000 dogs. Most dogs and approximately 30-40% of children with OS succumb to metastatic disease. We identified elevated insulin-like growth factor 2 mRNA ... -
T cell independent mechanisms for protection against Mycobacterium tuberculosis infection
The live attenuated Mycobacterium bovis strain Bacille Calmette Guérin (BCG) is a potent innate immune stimulator. Innate Immunity provides the host with the ability to immediately respond to invasion by pathogens and can ... -
Experimental and computational analysis of Caenorhabditis elegans small RNAs
Caenorhabditis elegans contains twenty-five Argonautes, of which, only ALG-1 and ALG-2 are known to interact with microRNAs (miRNAs). ALG-5 belongs to the AGO subfamily of Argonautes that includes ALG-1 and ALG-2, but its ... -
Metabolomics approach for examining synbiotic protection against infectious enteric pathogens, A
Infectious gastrointestinal diseases contribute to billions of global cases of human illness annually. Salmonella enterica serovar Typhimurium and human rotavirus represent two human health challenges, where escalating ... -
Selenium speciation determined by ICPMS: effects on fish diversity, solubility, and bioavailability to the bryophyte Hygrohypnum ochraceum in Fountain Creek, Colorado
Selenium (Se) is a micronutrient that can be present in high levels in aquatic environments which may result in toxic effects observed in aquatic wildlife. The levels in Fountain Creek Colorado are of special concern as ... -
Assessing and understanding the generation and function of RNA decay intermediates in non-insect borne flaviviruses
Cellular gene expression is an intricate process regulated on many levels that allows the cell to react correctly to stimuli or to maintain homeostasis. RNA viruses must act to preferentially drive production of their own ... -
Autism-associated δ-catenin G34S mutation promotes GSK3β-mediated premature δ-catenin degradation inducing neuronal dysfunction
δ-catenin is a crucial component of a synaptic scaffolding complex, which regulates synaptic structure and function in neurons. Loss of δ-catenin function is strongly associated with severe autism spectrum disorder (ASD) ... -
Zika virus noncoding sfRNA sequesters viral restriction factors involved in RNA splicing and nucleic acid editing
ZIka virus (ZIKV) is a single-stranded positive sense RNA flavivirus that is transmitted primarily by Aedes aegypti. To date, all vector-borne flaviviruses are known to generate stable subgenomic flavivirus RNAs (sfRNA), ... -
How stress affects rice: a characterization of the rice transcriptome during single and simultaneous abiotic and biotic stresses
Environmental stresses, both abiotic and biotic, are large contributors to pre-harvest crop loss. Abiotic stresses, such as drought, salinity, non-optimal temperature and others, are non-living factors in the environment ...
