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Design and evaluation of an instrumented microfluidic organotypic device and sensor module for organ-on-a-chip applications
Author(s):Richardson, Alec Evan
Date Issued:2020
Format:born digital; masters theses
Organ and tissue-on-a-chip technologies are powerful tools for drug discovery and disease modeling, yet many of these systems rely heavily on in vitro cell culture to create reductionist models of tissues and organs. ...
Atomic force microscopy: more than surface imaging
Author(s):Bishop, Terrance Tyler
Date Issued:2020
Format:born digital; masters theses
Atomic Force Microscopy (AFM) is a powerful imaging tool that has capabilities that go beyond the abilities of most other microscopes. Here, three examples of these capabilities were considered. First, the AFM was operated ...
Nitric oxide-releasing or generating surfaces for blood-contacting medical devices
Author(s):Zang, Yanyi
Date Issued:2020
Format:born digital; doctoral dissertations
Medical device-induced thrombosis is a major complication that impairs the expected performance of blood-contacting medical devices. Traditional anticoagulation therapies are used to reduce thrombus formation; however, ...
Computational approaches to predict drug response to cytotoxic chemotherapy
Author(s):Mannheimer, Joshua D.
Date Issued:2020
Format:born digital; doctoral dissertations
Cancer is the second leading cause of death in the United States. Statistically, within a lifetime there is slightly above a one-third chance of developing some form of cancer and a one in five chance of dying from the ...
Pharmacokinetic investigation of chloroquine analogues in cancer autophagy modulation, A
Author(s):Collins, Keagan P.
Date Issued:2020
Format:born digital; doctoral dissertations
Hydroxychloroquine (HCQ) is currently being investigated for safety and efficacy as an autophagy inhibitor in Phase I/II cancer clinical trials. It is the only clinically-approved autophagy inhibitor for use in cancer ...
Biomimetic and antimicrobial surfaces for orthopedic implants
Author(s):Wigmosta, Tara
Date Issued:2021
Format:born digital; doctoral dissertations
The number of total knee and hip replacement surgeries is expected to continue to rise in the United States. As such, the number of revision surgeries is also expected to rise. The two most common causes of failure for ...
Molecular diagnostic platforms for point-of-need pathogen detection
Author(s):Jain, Sidhartha
Date Issued:2021
Format:born digital; doctoral dissertations
Rapid, accurate, reliable nucleic acid testing (NAT) platforms are essential in the diagnosis and management of diseases. The inherent complexity associated with NAT requires that such testing be performed in centralized ...
Clinical importance of autophagy dependency and inhibition in cancer treatment
Author(s):Van Eaton, Kristen M.
Date Issued:2021
Format:born digital; doctoral dissertations
Autophagy, a lysosomal degradation recycling process, has a complex and context-dependent role in cancer. Certain cancers have been found to be inherently dependent on autophagy for survival regardless of the environment. ...
Vascular endothelium glycocalyx-mimetic surfaces designed for blood contacting devices
Author(s):Vlcek, Jessi
Date Issued:2021
Format:born digital; doctoral dissertations
Each year millions of blood-contacting devices are used in clinical scenarios, with contact durations designed to range anywhere from hours to years. Current blood-contacting devices can perform their intended purposes ...
Development of novel mechanical diagnostic techniques for early prediction of bone fracture healing outcome
Author(s):Wolynski, Jakob G.
Date Issued:2021
Format:born digital; doctoral dissertations
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