The electrical behavior of small compartments in neurons such as dendritic spines, synaptic terminals, and microvilli has been of interest for decades. Most of these fine structures are found in the dendrite, where most ...

Heart valve disease is a major concern in both developed countries with advanced ageing populations and undeveloped countries which experience a high incidence of rheumatism leading to valvular disease. To reduce mortality ...

In vitro liver models have many applications in disease modeling and drug screening. Micropatterned cocultures (MPCCs) of primary human hepatocytes (PHHs) and supportive stromal cells have been shown to display high hepatic ...

Drug-induced liver injury (DILI) continues to be a major problem for patient health and pharmaceutical expenditures, partially due to inadequacies of current model systems for predicting hepatotoxicity prior to clinical ...

Menisci are C-shaped fibrocartilaginous tissues responsible for distributing tibial-femoral contact pressure and are crucial for maintaining healthy joints and preventing osteoarthritis. Meniscal damage can be caused by ...

Synthesis of hydrogel networks capable of accurately replicating the biomechanical demands of musculoskeletal soft tissues continues to present a formidable materials science challenge. Current systems are hampered by ...

Proteins are polymers of amino acids that are essential for life, central to cellular function, and have applications in fields ranging from materials science to biomedicine. Proteins in nature are composed of 20 amino ...

The anterior cruciate ligament (ACL) is a dense collagenous structure that connects the femur to the tibia and is vital for joint stability. The ACL possesses complex time-dependent viscoelastic properties and functions ...

Suffering a spinal cord injury (SCI) can be physically, emotionally, and financially devastating. With the complex loading environment typically seen in SCI events, finite element (FE) computational models provide an ...

INTRODUCTION: Functional Movement Assessments (FMAs) have been gaining popularity for screening athletes to determine weaknesses that could increase risk for injury. A common movement among many FMAs is the bilateral ...