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- ItemOpen Access0.85 PW laser operation at 3.3 Hz and high-contrast ultrahigh-intensity λ = 400 nm second-harmonic beamline(Colorado State University. Libraries, 2017-09-22) Wang, Yong, author; Wang, Shoujun, author; Rockwood, Alex, author; Luther, Bradley M., author; Hollinger, Reed, author; Curtis, Alden, author; Calvi, Chase, author; Menoni, Carmen S., author; Rocca, Jorge J., author; Optical Society of America, publisherWe demonstrate the generation of 0.85 PW, 30 fs laser pulses at a repetition rate of 3.3 Hz with a record average power of 85 W from a Ti:sapphire laser. The system is pumped by high-energy Nd:glass slab amplifiers frequency doubled in LiB3O5 (LBO). Ultrahigh-contrast λ = 400 nm femtosecond pulses were generated in KH2PO4 (KDP) with>40% efficiency. An intensity of 6.5 × 1021 W∕cm2 was obtained by frequency doubling 80% of the available Ti:sapphire energy and focusing the doubled light with an f∕2 parabola. This laser will enable highly relativistic plasma experiments to be conducted at high repetition rate.
- ItemOpen Access08 CPG SFA NFP CG2 BO FRFT 53 08310-01 BMFPD REED REMB PBH(Colorado State University. Libraries, 2008-2010) Colorado State Forest Service, compiler
- ItemOpen Access08 HAZ FUELS BO STEVENS 53 6709 BOULDER CNTY REYNOLD PA2(Colorado State University. Libraries, 2010) Colorado State Forest Service, compiler
- ItemOpen Access08 HAZ FUELS BO STEVENS 536709-01 GOLD HILL/ASHRAM(Colorado State University. Libraries, 2008-2012) Colorado State Forest Service, compiler
- ItemOpen Access08 HB 71 CO FOREST RESTORATION GRANT 536703-03 BMFPD(Colorado State University. Libraries, 2008-2010) Colorado State Forest Service, compiler
- ItemOpen Access08CPG SFA-NFP CG2 BO FRFT 5308310 LEFTHAND/MTN RIDGE(Colorado State University. Libraries, 2008-2009) Colorado State Forest Service, compiler
- ItemOpen Access1 month effect of breaking up sedentary activity on insulin sensitivity and glucose homeostasis in free-living overweight/obese adults(Colorado State University. Libraries, 2019) Schreck, Laura M., author; Hickey, Matthew, advisor; Bergouignan, Audrey, advisor; Broussard, Josiane, committee member; Melby, Christopher, committee memberSedentary behavior (SB) triggers an inability to adjust substrate use to substrate availability (low metabolic flexibility, MF), which may precede glucose intolerance in the pathogenesis of insulin resistance. We and others have shown that frequent interruptions in SB leads to improved glycemic control, however the underlying role of MF in this process is unknown. This study examined the effects of breaking up SB on MF and glucose metabolism in free-living overweight and obese adults. To distinguish effects of breaking up SB from being physically active, we also studied a group where participants performed a single energy matched continuous bout of exercise. Physically inactive, adults (12F/9M, mean±SD, age: 33±8 yr, BMI: 29.5±3.3 kg/m2) were randomly assigned to a 4 week intervention consisting of brisk walking for 5 min each hour for 10h, 5 d/wk (MICRO, n=10), or 4 weeks of an intervention consisting of one continuous 45 min bout of exercise per day, 5d/wk (ONE, n=9). Outcomes assessed at baseline and after each intervention included: MF (waking respiratory quotient, RQ, minus sleeping RQ as measured in a whole room calorimeter), insulin sensitivity (SI, IVGTT), 24h glycemia (continuous glucose monitor), 24h glucose oxidation (U13C glucose tracer), SB, time spent standing, time spent stepping (ActivPAL) and TEE (double labeled water). Groups were similar on all outcome variables at baseline. Linear mixed models evaluated intervention and intervention-by-group effects. MICRO and ONE decreased time sitting and increased time stepping with no significant changes in TEE. Compared to ONE, MICRO decreased 24h glycemic variability (p=0.06), improved the acute whole body insulin sensitivity (p=0.08) and acute insulin response to glucose (AIRg) (p=0.02) , maintained exogenous glucose oxidation (p<0.03) and improved MF (p=0.02). Independent of time sitting and stepping, breaking up SB improves glucose homeostasis and MF. The effects of such an intervention in persons with type 2 diabetes warrants further study.