(Colorado State University. Libraries, 2008) Carsten, Ronald E., author; Ullrich, Robert L., advisor
Resveratrol has been shown to have cancer preventive properties. It modulates a wide range of molecular targets including those involved with induction of apoptosis and cell cycle arrest in a concentration dependent fashion. This study was designed to investigate resveratrol's ability to reduce radiation-induced chromosome aberrations and PU.1 gene loss in mouse bone marrow cells. Loss of 1 PU.1 gene and missense mutation of the remaining allele leads to acute myeloid leukemia in CBA mice.
