Browsing by Author "Perry, James A., author"
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Item Open Access The acquisition of dendritic cell tolerance during malaria infection results in differential T-cell activation(Colorado State University. Libraries, 2008) Perry, James A., author; Avery, Anne, advisorMalaria is caused by intracellular protozoan parasites belonging to the genus Plasmodia. These single cell eukaryotes have a complex life cycle requiring both mammalian (and in certain Plasmodium species, avian) and mosquito hosts. Clinical malaria in humans and other animals is the result of red blood cell (RBC) infection. Although infection direcdy destroys erythrocytes, causing anemia, a significant degree of anemia and morbidity is the result of the host immune response. Inflammatory cytokines have been implicated in the pathogenesis of severe malaria anemia (SMA) and cerebral malaria (CM), two diseases that are responsible for most malaria-related morbidity. Therefore, understanding the regulation of host immunity and inflammatory cytokine production during malaria infection will improve our understanding of malaria related illness.