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Theses and Dissertations

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Browsing Theses and Dissertations by Author "Beale, Melanie N., author"

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    Relationships between objectively measured physical activity and stool metabolome in individuals at high risk for colorectal cancer
    (Colorado State University. Libraries, 2019) Beale, Melanie N., author; Leach, Heather J., advisor; Ryan, Elizabeth P., advisor; Hickey, Matthew S., committee member; Melby, Chris L., committee member
    Physical activity is known to reduce the risk of colorectal cancer and adenomatous polyp recurrence. Targeted metabolomic profiling of the stool metabolome may provide insight to the mechanistic links between physical activity and colorectal cancer. This study utilized baseline physical activity and metabolomics data from a dietary fiber intervention for individuals at high risk for colorectal cancer. Participants (N=21), 59+/-9 years, BMI 28.1+/-3.35 wore an activPAL™ accelerometer for 7 consecutive days, provided a stool sample, and a 3-day dietary log. Stool bile acids and short chain fatty acids were quantified with gas chromatography mass spectroscopy and ultra-high performance liquid-chromatography tandem mass spectrometry. Linear regression models examined relationships between light intensity physical activity minutes, moderate to vigorous physical activity minutes, MET-hours per day, and sedentary minutes, with abundances of short chain fatty acids and bile acids while accounting for dietary fiber intake. Light intensity PA minutes predicted butyrate and propionate abundance when accounting for dietary fiber. MVPA predicted deoxycholic acid and ursodeoxycholic acid abundance. These data suggest that both low intensity PA and MVPA may both have implications for colorectal cancer primary and secondary prevention through different mechanisms.